Clinical Trials Updated in 2025

NCT05302999 | RECRUITING | PHASE4

42 participants

Feasibility of Early Gabapentin as an Intervention for Neurorecovery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-03-14
Completion:: 2026-08-31

Conditions

Spinal Cord Injuries

Interventions

DRUG

No Results Yet

NCT05287555 | COMPLETED | NA

54 participants

Efficacy of Telemetry-assisted Care in Home Home Vented COPD

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-04-25
Completion:: 2025-04-15

Conditions

Chronic Obstructive Pulmonary Disease

Interventions

OTHER

No Results Yet

NCT05282823 | COMPLETED

295 participants

POLARx™ Cardiac Cryoablation System Post Market Clinical Study (POLAR SMART)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-08-26
Completion:: 2024-10-29

Conditions

Paroxysmal Atrial Fibrillation

Interventions

DEVICE

Results Available

NCT05271773 | COMPLETED

234 participants

Impact of Therapeutic Intervention on Quality of Life in Patients With Ulcerative Colitis

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-11-18
Completion:: 2024-11-30

Conditions

IBD-Inflammatory Bowel Disease
UC - Ulcerative Colitis

No Results Yet

NCT05216770 | RECRUITING | EARLY_PHASE1

165 participants

Understanding Disorder-specific Neural Pathophysiology in Laryngeal Dystonia and Voice Tremor

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-03-24
Completion:: 2027-08-31

Conditions

Laryngeal Dystonia
Spasmodic Dysphonia
Tremor

Interventions

OTHER
DRUG

No Results Yet

NCT05207995 | COMPLETED | PHASE1/PHASE2

32 participants

The Treatment of Patients With Type 1 Diabetes Mellitus With Autologous Tolerogenic Dendritic Cells

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-03-01
Completion:: 2023-12-26

Conditions

Diabetes Mellitus

Interventions

BIOLOGICAL
OTHER

No Results Yet

NCT05204836 | TERMINATED | PHASE1

4 participants

Altering Bone Microarchitecture and Mechanics by Off-label Pharmaceutical Intervention Following an Acute Knee Injury

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2023-05-16
Completion:: 2025-07-03

Conditions

Anterior Cruciate Ligament Tear
Anterior Cruciate Ligament Rupture
Anterior Cruciate Ligament Injuries
Osteo Arthritis Knee

Interventions

DRUG

No Results Yet

NCT05150106 | RECRUITING

165 participants

Characterization of Clinical Phenotypes of Laryngeal Dystonia and Voice Tremor

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-11-07
Completion:: 2027-08-31

Conditions

Laryngeal Dystonia
Spasmodic Dysphonia
Tremor

Interventions

OTHER

No Results Yet

NCT05150093 | RECRUITING | NA

120 participants

Deep Brain Stimulation in Laryngeal Dystonia and Voice Tremor

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-06-21
Completion:: 2027-08-31

Conditions

Laryngeal Dystonia
Spasmodic Dysphonia
Tremor
Dystonia

Interventions

PROCEDURE

No Results Yet

NCT05147649 | RECRUITING | NA

70 participants

Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2023-03-02
Completion:: 2027-01-02

Conditions

Obstructive Sleep Apnea Syndrome

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT05100355 | COMPLETED | NA

92 participants

Management of the Lack of Blood Return on a Central Venous Catheter (CVC) Before Chemotherapy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-03-09
Completion:: 2025-02-26

Conditions

Catheter Dysfunction

Interventions

PROCEDURE

No Results Yet

NCT05083208 | TERMINATED | PHASE1

12 participants

PI3Kδ Inhibitor Parsaclisib Combined With Chidamide for the Treatment of Relapsed/Refractory Peripheral T-cell Lymphoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-02-20
Completion:: 2024-06-30

Conditions

Peripheral T-Cell Lymphoma

Interventions

DRUG

No Results Yet

NCT05063448 | COMPLETED | NA

20 participants

DadSpace: Increasing Community Support Resources for Perinatal Fathers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2021-08-06
Completion:: 2022-12-31

Conditions

Paternal Behavior
Father-Child Relations
Family Relations

Interventions

BEHAVIORAL

Results Available

NCT05035407 | TERMINATED | PHASE1

36 participants

T Cell Receptor Gene Therapy Targeting KK-LC-1 for Gastric, Breast, Cervical, Lung and Other KK-LC-1 Positive Epithelial Cancers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-03-08
Completion:: 2025-07-16

Conditions

Kita-kyushu Lung Cancer Antigen 1, Human

Interventions

DRUG
BIOLOGICAL
DIAGNOSTIC_TEST
PROCEDURE

Results Available

NCT05013229 | COMPLETED | PHASE3

679 participants

A Research Study to See How Well the New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Level in People With Type 2 Diabetes Compared to Insulin Glargine Taken Daily With Insulin Aspart (COMBINE 3)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2021-11-30
Completion:: 2023-11-14

Conditions

Diabetes Mellitus, Type 2

Interventions

DRUG

No Results Yet

NCT04971044 | ACTIVE_NOT_RECRUITING | NA

301 participants

Competency Based Approaches for Community Health 2

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2021-11-18
Completion:: 2026-10-31

Conditions

Obesity

Interventions

BEHAVIORAL

No Results Yet

NCT04970888 | RECRUITING | NA

216 participants

Comparing the Effects of Combining Cognitive and Physical Exercise Training on Cognition, and Cerebral Blood Flow Regulation in Men and Women With Chronic Heart Failure

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2021-09-01
Completion:: 2026-12-01

Conditions

Chronic Heart Failure
Aging

Interventions

OTHER

No Results Yet

NCT04964466 | ACTIVE_NOT_RECRUITING

5 participants

Release Kinetics in PRF Versus GEM21S With and Without Bone Substitutes: An In Vitro Analysis

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-02
Start Date:: 2021-08-31
Completion:: 2023-07-31

Conditions

Bone Loss

Interventions

BIOLOGICAL

No Results Yet

NCT04961840 | ACTIVE_NOT_RECRUITING

100 participants

A Study to Assess Maternal and Fetal Outcomes After Taking Prucalopride During Pregnancy

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-01-01
Completion:: 2026-12-31

Conditions

Constipation
Pregnancy

Interventions

OTHER

No Results Yet

NCT04953338 | COMPLETED

36104 participants

Mental Health Associations With Vitiligo

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-02
Start Date:: 2021-06-18
Completion:: 2022-08-30

Conditions

Vitiligo
Depressive Episode
Recurrent Depressive Disorder
Anxiety Disorders
Social Phobia
Adjustment Disorders
Substance Abuse
Self-Harm, Deliberate
Overdose
Suicide, Attempted
Parasuicide

Interventions

OTHER

Results Available

NCT04947670 | TERMINATED | NA

4 participants

A Prospective, Multicenter, Randomized, Blinded, Sham-controlled, Feasibility Study of Renal Denervation in Patients With Chronic Heart Failure

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-06-13
Completion:: 2024-09-06

Conditions

Chronic Heart Failure
Cardio-Renal Syndrome

Interventions

PROCEDURE

No Results Yet

NCT04943562 | RECRUITING

96 participants

Actigraphy, Wearable EEG Band and Smartphone for Sleep Staging

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-02
Start Date:: 2021-09-09
Completion:: 2021-12-12

Conditions

Sleep
Insomnia
Sleep Apnea Syndrome, Obstructive

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04941027 | COMPLETED

1046 participants

Evaluating Genetic Modifiers of Cutaneous Neurofibromas in Adults With Neurofibromatosis Type 1

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-02
Start Date:: 2021-05-07
Completion:: 2025-09-30

Conditions

Neurofibromatosis 1

No Results Yet

NCT04935879 | COMPLETED | PHASE3

241 participants

A Study to Assess the Safety and Efficacy of Inclacumab in Participants With Sickle Cell Disease Experiencing Vaso-occlusive Crises

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2021-10-04
Completion:: 2024-06-06

Conditions

Sickle Cell Disease
Vaso-occlusive Pain Episode in Sickle Cell Disease
Vaso-occlusive Crisis

Interventions

DRUG

Results Available

NCT04889417 | ACTIVE_NOT_RECRUITING | NA

250 participants

COgnitive and Physical Exercise to Improve Outcomes After Surgery (COPE-iOS) Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2021-10-12
Completion:: 2026-10-31

Conditions

Cognitive Impairment
Disability Physical
Surgery

Interventions

BEHAVIORAL

No Results Yet

NCT04865289 | COMPLETED | PHASE3

130 participants

Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) Versus Chemotherapy for Endometrial Carcinoma (ENGOT-en9 / MK-7902-001) - China Extension Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2019-10-22
Completion:: 2023-10-02

Conditions

Endometrial Neoplasms

Interventions

DRUG
BIOLOGICAL

Results Available

NCT04820036 | ACTIVE_NOT_RECRUITING | NA

20 participants

A Physiologic Analysis of Endoscopic Sleeve Gastroplasty (ESG)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2021-05-06
Completion:: 2026-12-24

Conditions

Non-alcoholic Steatohepatitis (NASH)
Endoscopic Sleeve Gastroplasty
Non-alcoholic Fatty Liver Disease (NAFLD)
Endoscopic Ultrasound
Liver Function
Obesity
Liver Fibroses

Interventions

DIAGNOSTIC_TEST
BEHAVIORAL

No Results Yet

NCT04817189 | COMPLETED | PHASE4

414 participants

Oral Akynzeo® vs Standard of Care in Preventing CINV in High-risk MEC Patients (MyRisk)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2021-02-01
Completion:: 2024-07-02

Conditions

Chemotherapy-induced Nausea and Vomiting

Interventions

DRUG

Results Available

NCT04815278 | COMPLETED | NA

455 participants

NC Works4Health: Reducing Chronic Disease Risks in Socioeconomically Disadvantaged, Unemployed Populations

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2021-09-17
Completion:: 2025-11-30

Conditions

Diabetes
Chronic Disease
Psychological Distress

Interventions

BEHAVIORAL

No Results Yet

NCT04787263 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

32 participants

CD19-CAR_Lenti T Cells in Pediatric Patients Affected by Relapsed/Refractory CD19+ ALL and DLBCL or PML

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2021-03-04
Completion:: 2027-03-31

Conditions

Acute Lymphoblastic Leukemia
Diffuse Large B Cell Lymphoma
Primary Mediastinal Lymphoma

Interventions

BIOLOGICAL

No Results Yet

NCT04771754 | COMPLETED | PHASE1

16 participants

The Effect of Dolutegravir on Whole-body Insulin Sensitivity, Lipid and Endocrine Profile in Healthy Volunteers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2022-03-20
Completion:: 2023-12-31

Conditions

HIV-1-infection on Healthy Volunteers

Interventions

DRUG

Results Available

NCT04747041 | ACTIVE_NOT_RECRUITING | NA

15 participants

Evaluation of a Phyto Aromatherapy Treatment in the Management of Recurrent Cystitis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2021-05-18
Completion:: 2023-06-20

Conditions

Cystitis Recurrent

Interventions

COMBINATION_PRODUCT

No Results Yet

NCT04741256 | WITHDRAWN | NA

0 participants

Implementation of a Standardized Tracheostomy Education Discharge Protocol

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2025-07-31
Completion:: 2025-12-31

Conditions

Head and Neck Cancer

Interventions

BEHAVIORAL

No Results Yet

NCT04735458 | RECRUITING | NA

140 participants

Investigating Inhibitory Control Networks in Parkinson's Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2021-04-01
Completion:: 2027-03-31

Conditions

Parkinson Disease

Interventions

OTHER

No Results Yet

NCT04680026 | ACTIVE_NOT_RECRUITING | PHASE2

150 participants

A Study of IV HBI-3000 for the Conversion Recent Onset Atrial Fibrillation (AF)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2021-06-01
Completion:: 2025-12-31

Conditions

Atrial Fibrillation

Interventions

DRUG

No Results Yet

NCT04659759 | COMPLETED

105 participants

COVID-19 Pregnancy Related Immunological, Clinical and Epidemiological Factors and Perinatal Outcomes

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-02
Start Date:: 2020-11-17
Completion:: 2025-08-30

Conditions

Covid19

Interventions

OTHER
BIOLOGICAL

No Results Yet

NCT04611516 | RECRUITING

1000 participants

The Ear-Nose-Throat (ENT) Prospective International Cohort of PCD Patients (EPIC-PCD)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-02
Start Date:: 2020-03-02
Completion:: 2030-12-31

Conditions

Primary Ciliary Dyskinesia
Kartagener Syndrome

No Results Yet

NCT04602481 | RECRUITING

1500 participants

Living With Primary Ciliary Dyskinesia (Living With PCD)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-02
Start Date:: 2020-05-31
Completion:: 2030-05-31

Conditions

Primary Ciliary Dyskinesia

No Results Yet

NCT04597580 | ACTIVE_NOT_RECRUITING

97 participants

Personalised Disease Monitoring in Metastatic Breast Cancer

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-02
Start Date:: 2019-05-08
Completion:: 2026-05-31

Conditions

Breast Cancer Metastatic
Estrogen Receptor-positive Breast Cancer

No Results Yet

NCT04594902 | ACTIVE_NOT_RECRUITING | NA

288 participants

The PANTHERS (Parents and iNfants Together in Home-based Early Remote Services) Project

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-02
Start Date:: 2021-03-08
Completion:: 2026-09-07

Conditions

Early Childhood Development
Behavior Problems

Interventions

BEHAVIORAL
OTHER

No Results Yet