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Altering Bone Microarchitecture and Mechanics by Off-label Pharmaceutical Intervention Following an Acute Knee Injury

NCT05204836 · Status: TERMINATED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 4

Last updated 2025-12-02

No results posted yet for this study

Summary

The purpose of this study is to assess if a zoledronic acid injection can alter the trajectory of joint degeneration following an acute anterior cruciate ligament (ACL) injury.

Conditions

  • Anterior Cruciate Ligament Tear
  • Anterior Cruciate Ligament Rupture
  • Anterior Cruciate Ligament Injuries
  • Osteo Arthritis Knee

Interventions

DRUG

Zoledronic Acid Injection

5 mg / 100 mL intravenous infusion

DRUG

Placebo

100 mL intravenous infusion

Sponsors & Collaborators

  • University of Calgary

    lead OTHER

Principal Investigators

  • Steven Boyd, PhD · University of Calgary

  • Gregory Kline, MD · University of Calgary

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
25 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-05-16
Primary Completion
2025-07-03
Completion
2025-07-03

Countries

  • Canada

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05204836 on ClinicalTrials.gov