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The Treatment of Patients With Type 1 Diabetes Mellitus With Autologous Tolerogenic Dendritic Cells

NCT05207995 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 32

Last updated 2025-12-02

No results posted yet for this study

Summary

The purpose of this study is to determine the safety and tolerability of the administration of tolerogenic dendritic cells in patients with type 1 diabetes mellitus.

Conditions

Interventions

BIOLOGICAL

Autologous tolerogenic dendritic cells

Autologous tolerogenic dendritic cells treated with Vitamin-D3, co-cultivated with mesenchymal stem cell and primed peptides (MSC-tolDC) injected subcutaneous.

OTHER

Standard treatment according to the clinical protocols

Standard treatment of type 1 diabetes mellitus according to the clinical protocols

Sponsors & Collaborators

  • Belarusian State Medical University

    collaborator OTHER

  • Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus

    lead OTHER_GOV

Principal Investigators

  • [email protected] Antonevich, Dr · the Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus

  • Tatiana Mokhort, Prof · Belarusian State Medical University

  • Andrei Y Hancharou, Dr. · The Institute for Biophysics and Cell Engineering of the NAS of Belarus

  • Yana S Minich · The Institute for Biophysics and Cell Engineering of the NAS of Belarus

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-03-01
Primary Completion
2023-12-26
Completion
2023-12-26

Countries

  • Belarus

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05207995 on ClinicalTrials.gov