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Postprandial Glucose Kinetics After Carbohydrate Restriction

NCT07802275 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 29

Last updated 2026-09-03

No results posted yet for this study

Summary

The goal of this study is to test whether a low-carbohydrate diet (LCD), comparred with a Mediterranean diet (MED) producing similar weight loss, differentially affects fasting and postprandial glucose metabolism in individuals with overweight and dysglycemia. The main questions it aims to answer are:

* Is oral glucose absorption delayed or reduced after chronic carbohydrate restriction?
* Is insulin sensitivity differentially affected? Participants will follow 4 weeks of LCD and 4 weeks of MED, in a random order, separated by a 4-week washout. After each intervention, participants will undergo a dual-tracer 75-g oral glucose tolerance test.

Conditions

  • Prediabetes
  • Obesity & Overweight
  • Diet Interventions
  • Carbohydrate Metabolism

Interventions

BEHAVIORAL

Low-carbohydrate diet

A 4-week diet providing 20% of total energy from carbohydrates, 55% from fat, and 25% from protein, with an energy restriction of 200-400 kcal/day relative to basal metabolic rate.

BEHAVIORAL

Mediterranean Diet

A 4-week diet providing 50% of total energy from carbohydrates, 30% from fat, and 20% from protein, with an energy restriction of 200-400 kcal/day relative to basal metabolic rate.

Sponsors & Collaborators

  • Azienda Ospedaliero, Universitaria Pisana

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-11-01
Primary Completion
2024-03-30
Completion
2026-08-30

Countries

  • Italy

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07802275 on ClinicalTrials.gov