Cold Versus Hot Snare Endoscopic Mucosal Resection for Intermediate-Size Flat Nonpedunculated Colorectal Polyps

Summary

This multicenter, prospective, randomized, non-inferiority trial aimed to compare the efficacy and safety of cold snare endoscopic mucosal resection (CS-EMR) and hot snare endoscopic mucosal resection (HS-EMR) for resection of intermediate-size (10-20 mm) flat nonpedunculated colorectal polyps.

Conditions

• Colorectal Polyps
• Endoscopic Mucosal Resection

Interventions

PROCEDURE

Cold snare endoscopic mucosal resection (CS-EMR)

During CS-EMR, methylene blue-stained epinephrine saline is injected into the submucosa surrounding the lesion to achieve submucosal lifting. The polyp together with 1-2 mm of adjacent mucosa is subsequently tightly snared and mechanically transected.

PROCEDURE

Hot snare endoscopic mucosal resection (HS-EMR)

During HS-EMR, methylene blue-stained epinephrine saline is injected into the submucosa surrounding the lesion to achieve submucosal lifting. The snare is positioned around the lesion, and electrocautery is delivered via the electrosurgical generator for transection.

Sponsors & Collaborators

• Shunde First People's Hospital of Foshan

  collaborator UNKNOWN

• Jiangmen Central Hospital

  collaborator OTHER

• ZhuHai Hospital

  collaborator OTHER

• Longgang District People's Hospital of Shenzhen

  collaborator OTHER

• Yangjiang People's Hospital

  collaborator OTHER

• The Third People's Hospital of Huizhou

  collaborator OTHER

• Longnan Traditional Chinese Medicine Hospital

  collaborator UNKNOWN

• Sihui Wanlong Hospital

  collaborator UNKNOWN

• Suixi People's Hospital of Zhanjiang

  collaborator UNKNOWN

• Guzhen People's Hospital of Zhongshan

  collaborator UNKNOWN

• Anyuan County People's Hospital of Ganzhou

  collaborator UNKNOWN

• Shaoguan First People's Hospital

  collaborator UNKNOWN

• Yangchun People's Hospital

  collaborator UNKNOWN

• ZhuZhou Central Hospital

  collaborator OTHER

• Nanfang Hospital, Southern Medical University

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-08-31

Primary Completion

2028-10-31

Completion

2029-02-28