Underwater Endoscopic Mucosal Resection Versus Endoscopic Submucosal Dissection for the Treatment of Small Rectal Neuroendocrine Tumors

Summary

Underwater endoscopic mucosal resection (UEMR) and endoscopic submucosal dissection (ESD) have both been reported to be two effective treatment methods for small rectal neuroendocrine tumor (NET). However, there is no consensus on the best method for the endoscopic resection of rectal NET. Therefore, we aimed to compare the efficacy and safety of UEMR and ESD for the treatment of small rectal NET.

Conditions

• Rectal Neuroendocrine Tumor

Interventions

PROCEDURE

UEMR procedure

Small rectal NET will be removed by underwater endoscopic mucosal resection. The UEMR procedure included the following: (1) complete deflation of the colorectal lumen; (2) total immersion of the lesion in normal saline using a mechanical water pump; (3)needle injection of normal saline into the submucosa; (4) snaring the lesion and the surrounding mucosa; and (5) resection using electrocautery.

PROCEDURE

ESD procedure

Small rectal NET will be removed by endoscopic submucosal dissection. The ESD procedure included the following: (1) dots were marked approximately 5 mm from the periphery of the lesion using coagulation; (2) a diluted sodium hyaluronate solution with indigo carmine dye was injected submucosally. (3) mucosal incision and submucosal dissection were performed using a T-Type ESD Knife (Micro-Tech, Nanjing, China) or Dual-knife (Olympus Medical, Tokyo, Japan); (4)after resection was completed, all visible vessels on the artificial wound were thoroughly coagulated to prevent postoperative bleeding.

Sponsors & Collaborators

• Guangdong Provincial Hospital of Traditional Chinese Medicine

  collaborator OTHER

• The Eighth Affiliated Hospital of Southern Medical University

  collaborator UNKNOWN

• ZhuHai Hospital

  collaborator OTHER

• Shenzhen Longgang District People's Hospital

  collaborator UNKNOWN

• Jiangmen Central Hospital

  collaborator OTHER

• Yangjiang People's Hospital

  collaborator OTHER

• The Third People's Hospital of Huizhou

  collaborator OTHER

• the Fifth Affiliated Hospital of Zunyi Medical University (Zhuhai)

  collaborator UNKNOWN

• Ganzhou City People's Hospital

  collaborator OTHER

• Nanfang Hospital, Southern Medical University

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-04-14

Primary Completion

2029-10-31

Completion

2029-12-31

Countries

• China

Study Locations