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Personalized Nutritional Formula for ICU Patients: A Study on Prognosis and Multidimensional Health Markers

NCT07755033 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 1200

Last updated 2026-08-10

No results posted yet for this study

Summary

This study aims to evaluate the effects of an individualized enteral nutrition formula on clinical outcomes in critically ill adult patients in the intensive care unit (ICU). Participants will be randomly assigned to one of two groups: the individualized nutrition group or the standard nutrition group. In the individualized group, the total daily amount of enteral nutrition will be calculated and adjusted daily based on the patient's resting energy expenditure (measured by indirect calorimetry) and serum protein levels. In the standard group, a fixed-dose formula will be administered according to routine clinical protocols recommended by current guidelines. The intervention will be initiated within 48 hours of ICU admission and continued for up to 14 days or until ICU discharge. The study will assess clinical prognosis, as well as changes in gut and pulmonary microbiota, serum metabolomics, and macronutrient balance. The findings may provide evidence for personalized nutrition strategies in critically ill patients.

Conditions

  • Sepsis
  • Nutrition
  • Gut -Microbiota

Interventions

DIETARY_SUPPLEMENT

Individualized Enteral Nutrition Formula

Individualized Enteral Nutrition Formula Based on Daily Metabolic Measurements

DIETARY_SUPPLEMENT

Standard Enteral Nutrition Formula

Standardized enteral nutrition formula will be administered according to the routine clinical protocol recommended by current guidelines.

Sponsors & Collaborators

  • Chinese Medical Association

    lead NETWORK

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-07-28
Primary Completion
2027-07-27
Completion
2028-12-31

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Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07755033 on ClinicalTrials.gov