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Relationships Among Pupil Responses to Light, Circadian Rhythms, and Sleep

NCT07753889 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2026-08-10

No results posted yet for this study

Summary

The investigators are studying relationships among eye pathology, pupil responses to light, sleep, circadian rhythms, and hormones in healthy individuals and those with various medical disorders or illnesses.

All participants will:

* Answer questionnaires about their health
* Receive an eye exam,
* For one week at home, participants will track their sleep and wake using actigraphy (wrist worn wearable) and an online sleep diary.
* Complete a pupillometry session (measuring pupil size in response to different lighting) at MGH

Participants may also choose to participate in the following additional procedures in any order:

* Within one week of their pupillometry session, an at-home saliva collection under dim light. Saliva melatonin can be analyzed to determine Dim-Light-Melatonin-Onset (DLMO), a marker of circadian timing.
* If participants participate in one night saliva collection, a second night of at-home saliva collection with a bright light exposure to calculate melatonin suppression in response to light.

Conditions

  • Circadian Rhythm
  • Pupillometry
  • Sleep

Interventions

OTHER

Ocular light exposure from portable light box

One night of dim light exposure and one night of bright light exposure. Lighting from the portable light box

Sponsors & Collaborators

Principal Investigators

  • Elizabeth Klerman, MD PhD · MGB

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-09-01
Primary Completion
2034-12-31
Completion
2035-12-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07753889 on ClinicalTrials.gov