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Role of Progesterone Membrane Receptors in the Pathogenesis of Preeclampsia

NCT07745036 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 90

Last updated 2026-08-04

No results posted yet for this study

Summary

Preeclampsia is a pregnancy-specific hypertensive disorder and remains a leading cause of maternal and perinatal morbidity and mortality worldwide. Although abnormal placentation, impaired trophoblast invasion, endothelial dysfunction, and immune dysregulation have been implicated in its pathogenesis, the underlying molecular mechanisms are not fully understood.

Progesterone plays a critical role in the maintenance of pregnancy through both classical nuclear receptors and membrane-associated progesterone receptors. Emerging evidence suggests that progesterone membrane receptors, including progesterone receptor membrane component 1 (PGRMC1), progesterone receptor membrane component 2 (PGRMC2), and members of the progestin and adipoQ receptor (PAQR) family, may regulate trophoblast invasion, placental development, and inflammatory responses.

This study aims to compare the placental expression levels of PGRMC1, PGRMC2, and PAQR family receptors between women with preeclampsia and healthy pregnant controls and to investigate their potential role in the pathophysiology of preeclampsia.

Conditions

Sponsors & Collaborators

  • Samsun University

    lead OTHER

Principal Investigators

  • Canan Soyer Çalışkan, MD, Associate Professor · Samsun University Faculty of Medicine, Samsun Training and Research Hospital

  • Soyer Çalışkan · Samsun University Faculty of Medicine, Samsun Training and Research Hospital

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-09-01
Primary Completion
2027-01-01
Completion
2027-01-15

Countries

  • Turkey (Türkiye)

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07745036 on ClinicalTrials.gov