Preeclampsia is a hypertensive disorder of pregnancy with maternal organ dysfunction, usually after 20 weeks' gestation, and can progress to severe maternal and fetal complications.
Phase I CARLYSLE trial data show CAR-T therapy obe-cel induces remission in severe refractory lupus with a favorable safety profile. Separate case report documents two successful pregnancies after dual-target CAR-T therapy with no transmission to infants.
A large international study published in eClinicalMedicine found that COVID-19 booster vaccination was tied to a 33% lower risk of preeclampsia in pregnant women across 18 countries. Getting COVID during pregnancy increased preeclampsia risk by 78% in unvaccinated women, but vaccination with a booster reduced those odds significantly.
Amneal Pharmaceuticals recalls magnesium sulfate after a pouch intended for pregnant women was found containing tranexamic acid instead. The medication mix-up could cause serious adverse events including seizures and blood clotting if administered incorrectly.
New research from 18 countries shows COVID-19 vaccination during pregnancy, particularly with booster doses, significantly reduces the risk of preeclampsia and other serious complications for both mothers and babies.
The Preeclampsia Foundation released a new educational resource to help OB-GYNs navigate predictive and diagnostic biomarker testing for hypertensive disorders of pregnancy, covering FDA-cleared tests from Thermo Fisher Scientific and Roche Diagnostics.
A trial at Tygerberg Hospital in Cape Town tested DM199, a drug originally developed for stroke, in pregnant women with severe preeclampsia. The drug stabilized dangerously high blood pressure after researchers found the effective dose in the 16th patient.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07779057 |
Comparison of High- Versus Low-Dose Aspirin for Pregnancy Outcomes in Women at High Risk of Preeclampsia |
RECRUITING | PHASE4 |
| NCT07778966 |
Community Health Worker Support to Lower Blood Pressure After a Pregnancy With High Blood Pressure |
NOT_YET_RECRUITING | NA |
| NCT07745036 |
Role of Progesterone Membrane Receptors in the Pathogenesis of Preeclampsia |
RECRUITING | |
| NCT07728656 |
Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Pregnant Women With Hypertensive Disorders of Pregnancy |
RECRUITING | |
| NCT07717931 |
Vitamin D Therapy to Prevent Recurrent Preeclampsia in High-Risk Pregnancies |
COMPLETED | PHASE4 |
| NCT07715669 |
Antidepressant Therapy for Improved Blood Vessel Health After Preeclampsia |
RECRUITING | EARLY_PHASE1 |
| NCT07703826 |
Identification of Genes of Interest for Severe Forms of Preeclampsia |
NOT_YET_RECRUITING | |
| NCT07669935 |
Advancing Stillbirth Prevention Through Innovative Risk Evaluation (ASPIRE) Clinical Study |
NOT_YET_RECRUITING | |
| NCT07665853 |
Optimizing the Use of Aspirin for the Prevention of Preeclampsia |
NOT_YET_RECRUITING | PHASE3 |
| NCT07656532 |
Polyphenol Intake, Mediterranean Diet Adherence, and Oxidative Stress in Pregnancy |
NOT_YET_RECRUITING | NA |
