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PyroEVs/PLIN3 Mediate Lipid Droplet-Mitochondrial Coupling in Sepsis Endothelial Injury

NCT07727265 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 180

Last updated 2026-07-27

No results posted yet for this study

Summary

Objective: To investigate the correlation of PyroEVs and PLIN3 with the severity and prognosis of sepsis patients.

Participants: Sepsis patients meeting the Sepsis 3.0 diagnostic criteria admitted to the Intensive Care Unit of Zhongda Hospital affiliated with Southeast University, as well as healthy volunteers.

Inclusion Criteria:

1. Presence of confirmed or suspected infection;
2. Sequential Organ Failure Assessment (SOFA) score increase ≥ 2 points from baseline;
3. Signed informed consent. Exclusion Criteria: Age \< 18 or \> 80 years, pregnancy, cancer patients, and individuals with diseases potentially complicated by vascular endothelial cell injury.

Primary outcome: 28-day mortality, SOFA score

Conditions

Interventions

OTHER

No Intervention: Observational Cohort

No intervention

Sponsors & Collaborators

  • Zhongda Hospital

    lead OTHER

Principal Investigators

  • Yi Yang · Zhongda Hospital

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-07-01
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • China

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07727265 on ClinicalTrials.gov