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PLatelets Acetyl-CoA Carboxylase Phosphorylation State in SEPtic Shock

NCT04107402 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 150

Last updated 2025-04-15

No results posted yet for this study

Summary

Knowing the dramatic increase in thrombin generation during sepsis, our research hypothesis is that AMPK-induced ACC phosphorylation in platelets is increased and that this might modulate platelets metabolism and more particularly platelets inflammatory mediators content, coming from AA and lipids.

Conditions

  • Septic Shock
  • Platelet Signal Processing Defect
  • Inflammatory Response
  • Disseminated Intravascular Coagulation
  • Covid19
  • Neutrophil Extracellular Trap Formation

Interventions

OTHER

Assessment of coagulopathy, Platelets activation and Platelets-Neutrophils interplay

Blood sample Urine Sample Pulmonary, hepatic and cardiac tissue from biopsy and autopsy

Sponsors & Collaborators

  • Cliniques universitaires Saint-Luc- Université Catholique de Louvain

    lead OTHER

Principal Investigators

  • Christophe Beauloye, MD · Cliniques Universitaires St Luc

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-03-15
Primary Completion
2021-03-15
Completion
2024-03-15

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04107402 on ClinicalTrials.gov