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Low-FODMAP vs Lactose-Gluten-Free Diet in Patients With Irritable Bowel Syndrome

NCT07722572 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 72

Last updated 2026-07-23

No results posted yet for this study

Summary

Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder that substantially affects quality of life. Dietary therapy is considered one of the primary treatment approaches; however, the optimal sequence of dietary interventions remains unclear. This randomized crossover trial was designed to compare the effects of a low-FODMAP diet and a lactose-free, gluten-free diet on gastrointestinal symptoms, psychological status, anthropometric measurements, and biochemical parameters in adults with IBS. Participants were randomly assigned to one of two dietary sequences, with each intervention lasting four weeks and separated by a one-week washout period. Outcomes were assessed using validated symptom and psychological questionnaires together with anthropometric and biochemical measurements before and after each intervention period.

Conditions

  • Irritable Bowel Syndrome

Interventions

BEHAVIORAL

Low-FODMAP Diet

Participants followed a low-FODMAP diet for 4 weeks under the supervision of a dietitian.

BEHAVIORAL

Lactose- and Gluten-Free Diet

Participants followed a lactose- and gluten-free diet for 4 weeks under the supervision of a dietitian.

Sponsors & Collaborators

  • Antalya Bilim University

    lead OTHER

Principal Investigators

  • Hatice Kübra Aras · Antalya Bilim University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
64 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-09-01
Primary Completion
2021-11-25
Completion
2022-01-20

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07722572 on ClinicalTrials.gov