Glycolytic Phenotype (vLapeak) and Magnitude of Skeletal Muscle Hypertrophy After Resistance Training

Summary

The HyperLa study investigates whether a person's "glycolyticness"-the efficiency with which their body uses glycolysis for energy-can predict how much their muscles will grow (hypertrophy) in response to resistance training. Participants will undergo a specialized "vLapeak" test, which measures the maximal rate of lactate accumulation during a 10-second all-out cycling sprint, to determine their individual glycolytic power. Following this initial assessment, participants will complete eight weeks of standardized, twice-weekly resistance training focused on the lower body. The study aims to determine if individuals with higher initial vLapeak values experience greater increases in muscle size compared to those with lower values. This research may help explain why people respond differently to exercise and support the development of personalized training programs.

Conditions

• Healthy Volunteers
• Muscle Hypertrophy
• Glycolysis
• Moderately Trainend

Interventions

BEHAVIORAL

Hypertrophy-focused Resistance Training

Standardized training consisting of twice-weekly supervised sessions for 8 weeks. Each session includes 4 sets of 8-12 repetitions of leg press (or Smith-machine squat) and leg extensions. Training intensity progresses from an RPE of 6 to voluntary muscular failure starting from week three.

Sponsors & Collaborators

• Chemnitz University of Technology

  collaborator OTHER

• DLR German Aerospace Center

  collaborator OTHER

• University of Jyvaskyla

  collaborator OTHER

• University of Limerick

  collaborator OTHER

• IST University of Applied Sciences Düsseldorf

  collaborator UNKNOWN

• Institute for Applied Training Science (IAT/FES e.V.)

  collaborator UNKNOWN

• Technical University of Munich

  lead OTHER

Study Design

Allocation

NA

Purpose

TREATMENT

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Max Age

39 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2026-05-04

Primary Completion

2026-12-01

Completion

2026-12-01

Countries

• Finland
• Germany
• Ireland
• Spain

Study Locations