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High- and Low-Load Resistance Training

NCT07412600 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 22

Last updated 2026-02-18

No results posted yet for this study

Summary

The goal of this clinical trial is to learn whether low-load resistance training performed to muscle failure can produce similar increases in muscle size and strength as high-load resistance training in healthy untrained young adult males.

The main questions it aims to answer are:

Does low-load resistance training (30% of one-repetition maximum) performed to failure increase muscle strength and muscle size to a similar extent as high-load resistance training (75% of one-repetition maximum)?

Are there differences in total training volume between low-load and high-load resistance training programs performed to failure?

Researchers will compare a low-load resistance training group to a high-load resistance training group to determine whether the magnitude of changes in muscle strength and hypertrophy differs between the two approaches.

Participants will:

Be randomly assigned to either a low-load (30% 1RM) or high-load (75% 1RM) resistance training group

Perform supervised leg extension exercises to the point of voluntary muscle fatigue three times per week for 6 weeks

Complete muscle strength testing (one-repetition maximum) before and after the training period

Undergo ultrasound measurements to assess muscle thickness and cross-sectional area of thigh muscles before and after the intervention

Conditions

  • Resistance Training
  • Muscle Hypertrophy

Interventions

OTHER

Low-load resistance training (30% 1RM)

Participants perform unilateral or bilateral leg extension exercise at 30% of their individually determined one-repetition maximum (1RM). Each training session consists of sets performed to volitional muscular failure. Training is conducted three times per week for 6 weeks under direct supervision. Load is adjusted if necessary to maintain the target relative intensity. All repetitions are performed using a controlled movement tempo.

OTHER

High-load resistance training (75% 1RM)

Participants perform the same leg extension exercise at 75% of their individually determined one-repetition maximum (1RM). As in the LLRT group, sets are performed to volitional muscular failure. Training frequency (three sessions per week), duration (6 weeks), supervision, exercise selection, and movement tempo are identical to the LLRT group.

Sponsors & Collaborators

  • Selcuk University

    collaborator OTHER

  • Akdeniz University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
28 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-12-18
Primary Completion
2022-06-20
Completion
2022-07-02

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07412600 on ClinicalTrials.gov