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Effects of Resistance Training Preconditioning on Skeletal Muscle Recovery From a Period of Disuse in Young Adults

NCT05760066 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2023-03-08

No results posted yet for this study

Summary

The goal of this clinical trial is to compare the effects of resistance training (RT) preconditioning vs no training on disuse-induced atrophy and post-disuse resistance training in young healthy individuals. The main questions it aims to answer are:

* To determine if performing RT prior to a period of disuse enhances the regain of strength, skeletal muscle size, and skeletal muscle quality while performing RT after a period of disuse.
* To determine if performing RT prior to a period of disuse dampens the maladaptive effects of disuse on muscle size, muscle quality, and strength.
* To determine the anabolic and proteolytic mechanisms underpinning the observed outcomes.

Participants will:

1. Perform either 6 weeks of resistance training or maintain an untrained lifestyle
2. Perform 2 weeks of limb immobilization induced disuse of a randomized leg
3. Perform 6 weeks of resistance training

Researchers will compare the resistance training preconditioning condition vs the non-trained condition to see if resistance training prior to a period of disuse is beneficial during the disuse period and in the return to training period on skeletal muscle size, strength, and underpinning molecular markers.

Conditions

  • Atrophy, Disuse
  • Atrophy, Muscular

Interventions

OTHER

Resistance Training Preconditioning

Resistance training prior to disuse-induced atrophy followed by another period of resistance training

OTHER

Control

Activities of daily living prior to disuse-induced atrophy followed by a period of resistance training

Sponsors & Collaborators

  • Auburn University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-08-01
Primary Completion
2023-12-31
Completion
2024-08-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05760066 on ClinicalTrials.gov