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Evaluation of Salivary Biomarkers in Individuals With Bruxism

NCT07702019 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 56

Last updated 2026-07-14

No results posted yet for this study

Summary

The goal of this observational study is to evaluate salivary biomarkers and perceived stress in adults with bruxism compared with healthy individuals. The study aims to determine whether salivary cortisol, immunoglobulin A (IgA), free kappa light chain (FLC-κ), free lambda light chain (FLC-λ), total free light chains, and perceived stress levels differ between individuals with bruxism and healthy controls. The main questions it aims to answer are:

* Do salivary cortisol, IgA, FLC-κ, FLC-λ, and total free light chain levels differ between individuals with bruxism and healthy controls?
* Is perceived stress associated with changes in salivary biomarkers in individuals with bruxism? Researchers will compare participants with bruxism and healthy control participants to evaluate differences in salivary biomarker levels and perceived stress.

Participants will:

* undergo a clinical examination for the diagnosis of bruxism or confirmation of healthy status;
* complete the Perceived Stress Scale (PSS-14) questionnaire;
* provide an unstimulated saliva sample for laboratory analysis of cortisol, IgA, free kappa light chain, free lambda light chain, and total free light chains.

Conditions

  • Bruxism

Sponsors & Collaborators

  • Cumhuriyet University

    collaborator OTHER

  • Giresun University

    lead OTHER

Principal Investigators

  • Tugce Cevik Sonmez, DDS · Giresun University Faculty of Dentistry

Eligibility

Min Age
25 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-05-04
Primary Completion
2026-04-30
Completion
2026-06-15

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07702019 on ClinicalTrials.gov