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Adjunctive Oral Probiotics in Endodontic Retreatment: Effects on Postoperative Pain and RANKL/OPG Levels

NCT07683520 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 72

Last updated 2026-07-06

No results posted yet for this study

Summary

This study aimed to evaluate the effect of oral administration of probiotics as an adjunctive treatment to local intracanal medicaments, namely propolis and calcium hydroxide or empty canal, on the levels of receptor activator of nuclear factor kappa B ligand (RANKL) and osteoprotegerin (OPG), as well as on postoperative pain following root canal retreatment of teeth with chronic apical periodontitis

Conditions

  • Chronic Apical Periodontitis

Interventions

DIETARY_SUPPLEMENT

Linex Adult®

Linex Adult® is an oral probiotic formulation containing Lactobacillus acidophilus, Bifidobacterium animalis, It is administered as one capsule once daily for 21 days.

DRUG

Ca(OH)2 as intracanal medicament

Intracanal medication kept for 21 days

OTHER

Placebo

Placebo capsule for 21 days

DRUG

propolis intracanal medication

Intracanal medication kept for 21 days

OTHER

Empty canal

Empty canal for 21 days

Sponsors & Collaborators

  • Ain Shams University

    lead OTHER

Principal Investigators

  • Abeer A.Elhakim El Gendy, PHD, Professor of Endodontics · Ainshams university

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-10-04
Primary Completion
2026-06-04
Completion
2026-06-20

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07683520 on ClinicalTrials.gov