MedTrace Logo

Antimicrobial Effect of Calcium Silicate and Pectin as Intracanal Medications in Necrotic Teeth With Periapical Lesions

NCT07423663 · Status: ACTIVE_NOT_RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 63

Last updated 2026-02-20

No results posted yet for this study

Summary

It is tackling antimicrobial resistance in endodontics, specifically comparing different intracanal medications used in root canal treatment. Given the growing concern over resistant bacterial strains, our study aims to evaluate the effectiveness of various medicaments in eliminating endodontic pathogens while minimising the risk of resistance development. By integrating microbiological analysis and clinical relevance, our research seeks to provide evidence-based recommendations for optimising intracanal disinfection protocols and improving treatment outcomes in endodontic infections.

Conditions

  • Asymptomatic Apical Periodontitis

Interventions

DRUG

Calcium Hydroxide Intracanal medication

Patients receiving CaOH (Metapaste) intracanal medication

DRUG

Calcium silicate based intracanal medication

Patients receiving Calcium silicate based (Bio-C Temp) intracanal medication

DRUG

Pectin

Patients receiving Pectin intracanal medication

Sponsors & Collaborators

  • University of Leeds

    collaborator OTHER

  • Suez Canal University

    lead OTHER

Principal Investigators

  • Omar Montaser, M.D.Sc · Suez Canal University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
21 Years
Max Age
49 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-09-01
Primary Completion
2026-03-10
Completion
2026-04-01

Countries

  • Egypt

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07423663 on ClinicalTrials.gov