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Uppsala Self-Screening of Cardiovascular Health (U-SCREEN)

NCT07614659 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 45000

Last updated 2026-05-29

No results posted yet for this study

Summary

U-SCREEN is a randomized controlled trial evaluating whether systematic home-based multimodal screening for cardiovascular risk conditions, offered to residents in Region Uppsala turning 50, 55, 60, 65, 70 or 75 years of age, can identify clinically actionable cardiovascular risk factors more effectively than usual care. Participants randomized to the screening arm receive a home blood pressure measurement device, a dried blood spot sampling kit (for ApoB, HbA1c and creatinine), and a digital questionnaire. The control arm receives usual care. Recruitment runs 2024-2027 with a target identification of 10,000 cardiovascular risk conditions.

Conditions

Interventions

BEHAVIORAL

Home-based multimodal cardiovascular screening

Self-administered home-based screening program: 7-day home BP, DBS biomarker self-sampling, digital questionnaire; structured digital return of results; threshold-based initiation of guideline-recommended pharmacotherapy and referral to clinical care.

Sponsors & Collaborators

  • Region of Uppsala

    collaborator UNKNOWN

  • Johan Sundström

    lead OTHER

Principal Investigators

  • Johan Sundström, MD, PhD · Uppsala University

  • Anders Wanhainen, MD, PhD · Uppsala University

Study Design

Allocation
RANDOMIZED
Purpose
SCREENING
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
50 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-02-01
Primary Completion
2027-12-31
Completion
2037-12-31

Countries

  • Sweden

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07614659 on ClinicalTrials.gov