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100-Year Human Aging Study

NCT07563777 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 10000

Last updated 2026-05-04

No results posted yet for this study

Summary

The 100-Year Human Aging Study is a prospective, pragmatic, observational trial enrolling participants across fixed and mobile clinical sites to undergo comprehensive multi-system health screening and longitudinal follow-up until death. Participants are followed to determine whether measurements taken at enrollment and repeated across the lifespan - individually and in combination - predict all-cause mortality, cause-specific mortality, incident serious disease, and functional disability. The study is designed to generate the surrogate endpoint validation data that longevity medicine currently lacks.

Conditions

Interventions

DIAGNOSTIC_TEST

Comprehensive Multi-System Clinical Screening

Comprehensive multi-system clinical screening battery including cardiopulmonary exercise testing, body composition assessment by DEXA, echocardiography, electrocardiography, spirometry, neurocognitive testing, sensory assessment, metabolic testing, physical examination, and detailed medical, social, occupational, and environmental history. Participants receive individualized clinical findings and investigational longevity constructs at the conclusion of screening.

Sponsors & Collaborators

  • Longevity Metrics, Inc.

    lead INDUSTRY

Principal Investigators

  • William E Brandenburg, MD · Longevity Metrics, Inc.

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-02-09
Primary Completion
2099-12-31
Completion
2099-12-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07563777 on ClinicalTrials.gov