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Impact of Electronic Cigarette Temperature and Solvent on Biomarkers

NCT07612696 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2026-05-29

No results posted yet for this study

Summary

This project seeks to determine how e-cigarette (EC) physical design features, including those that allow the user to manipulate the quality and quantity of aerosols, affect exposure and toxicity from oxidants and other aerosol constituents.

Conditions

  • Oxidative Stress
  • Tobacco Use
  • Electronic Cigarettes

Interventions

OTHER

High temperature wattage setting on electronic cigarette

Study provided electronic cigarette will be set to a high wattage resulting in a higher usage temperature (275 C)

OTHER

Low temperature wattage setting on electronic cigarette

Study provided electronic cigarette will be set to a low wattage resulting in a lower usage temperature (200 C)

OTHER

High concentration of Propylene Glycol

Study provided electronic cigarette liquid will have a higher percentage of propylene glycol (90%)

OTHER

Low concentration of Propylene Glycol

Study provided electronic cigarette liquid will have a higher percentage of propylene glycol (10%)

Sponsors & Collaborators

  • National Institute on Drug Abuse (NIDA)

    collaborator NIH

  • Milton S. Hershey Medical Center

    lead OTHER

Principal Investigators

  • Zachary Bitzer, Ph.D. · Penn State Hershey College of Medicine

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-06-30
Primary Completion
2028-08-31
Completion
2028-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07612696 on ClinicalTrials.gov