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Validation of Biomarkers of Exposure and Host Response

NCT00468234 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2023-08-31

No results posted yet for this study

Summary

This study will evaluate biomarkers measured in exhaled breath condensate (EBC) to assess clinical strategies of harm reduction. It will take advantage of a recently developed device that permits collection of exhaled breath condensate reproducibly, with minimal subject effort and with no oral contamination. Samples from asymptomatic smokers before and after inducing a change in their smoking habit (cessation or reduction) with the aid of partial nicotine replacement.

Conditions

  • Cigarette Smoker

Interventions

DRUG

nicotine polacrilex

DRUG

nicotine transdermal system

DRUG

nicotine inhaler

Sponsors & Collaborators

  • Institute for Science and Health

    collaborator UNKNOWN

  • University of Nebraska

    lead OTHER

Principal Investigators

  • Stephen I Rennard, MD · University of Nebraska

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
19 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2005-12-31
Primary Completion
2007-09-30
Completion
2007-09-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00468234 on ClinicalTrials.gov