Effect of Different E-cigarette Cooling Flavors on Adults' Sensory Experience TCORS 3.0

Summary

This pilot sensory experiment will examine cooling from comparable concentrations of WS-3 and menthol to determine appropriate concentrations to use in the main study.

Conditions

• E-Cig Use

Interventions

OTHER

E-liquid coolant (WS-3, 0.05%)

Adult users of e-cigarette will be exposed to five e-liquid coolants WS-3: 0.05%.

OTHER

E-liquid coolant (WS-3, 0.1%)

Adult users of e-cigarette will be exposed to five e-liquid coolants WS-3: 0.1%.

OTHER

E-liquid coolant (WS-3, 0.5%)

Adult users of e-cigarette will be exposed to five e-liquid coolants WS-3: 0.5%.

OTHER

E-liquid coolant (WS-3, 1.0%)

Adult users of e-cigarette will be exposed to five e-liquid coolants WS-3: 1.0%.

OTHER

E-liquid coolant (WS-3, 2.0%)

Adult users of e-cigarette will be exposed to five e-liquid coolants WS-3: 2.0%.

OTHER

E-liquid coolant (menthol, 0.05%)

Adult users of e-cigarette will be exposed to five e-liquid coolants menthol: 0.05%.

OTHER

E-liquid coolant (menthol, 0.1%)

Adult users of e-cigarette will be exposed to five e-liquid coolants menthol: 0.1%.

OTHER

E-liquid coolant (menthol, 0.5%)

Adult users of e-cigarette will be exposed to five e-liquid coolants menthol: 0.5%.

OTHER

E-liquid coolant (menthol, 1.0%)

Adult users of e-cigarette will be exposed to five e-liquid coolants menthol: 1.0%.

OTHER

E-liquid coolant (menthol, 2.0%)

Adult users of e-cigarette will be exposed to five e-liquid coolants menthol: 2.0%.

OTHER

E-liquid coolant (WS-23, 0.05%)

Adult users of e-cigarette will be exposed to six e-liquid coolants WS-23: 0.05%.

OTHER

E-liquid coolant (WS-23, 0.1%)

Adult users of e-cigarette will be exposed to six e-liquid coolants WS-23: 0.1%.

OTHER

E-liquid coolant (WS-23, 0.5%)

Adult users of e-cigarette will be exposed to six e-liquid coolants WS-23: 0.5%.

OTHER

E-liquid coolant (WS-23, 1.0%)

Adult users of e-cigarette will be exposed to six e-liquid coolants WS-23: 1.0%.

OTHER

E-liquid coolant (WS-23, 2.0%)

Adult users of e-cigarette will be exposed to six e-liquid coolants WS-23: 2.0%.

OTHER

E-liquid coolant (WS-23, 4.0%)

Adult users of e-cigarette will be exposed to six e-liquid coolants WS-23: 4.0%.

Sponsors & Collaborators

• National Institute on Drug Abuse (NIDA)

  collaborator NIH

• Yale University

  lead OTHER

Principal Investigators

• Suchitra Krishnan-Sarin, PhD · Yale University

Study Design

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-09-03

Primary Completion

2025-01-09

Completion

2025-01-09

Countries

• United States

Study Locations