Effects of Electronic Cigarette Settings and Liquid Concentrations in Cigarette Smokers and Electronic Cigarette Users

Summary

The purpose of this research study is to find out how different types of electronic cigarettes (ECIG) settings, combined with e-liquids of differing nicotine concentrations, affect blood nicotine levels, use behavior (how users puff), and how users feel.

Conditions

• Electronic Cigarettes

Interventions

OTHER

ECIG Lab Session 15 watts, 10 mg nicotine

During each session, participants will first complete a 10-puff product use bout, and then a 90-minute ad lib product use bout.

OTHER

ECIG Lab Session 15 watts, 15 mg nicotine

During each session, participants will first complete a 10-puff product use bout, and then a 90-minute ad lib product use bout.).

OTHER

ECIG Lab Session 15 watts, 30 mg nicotine

During each session, participants will first complete a 10-puff product use bout, and then a 90-minute ad lib product use bout.

OTHER

ECIG Lab Session 30 watts, 10 mg nicotine

During each session, participants will first complete a 10-puff product use bout, and then a 90-minute ad lib product use bout.

OTHER

ECIG Lab Session 30 watts, 15 mg nicotine

During each session, participants will first complete a 10-puff product use bout, and then a 90-minute ad lib product use bout.

OTHER

ECIG Lab Session 30 watts, 30 mg nicotine

During each session, participants will first complete a 10-puff product use bout, and then a 90-minute ad lib product use bout.

Sponsors & Collaborators

• National Institute on Drug Abuse (NIDA)

  collaborator NIH

• Virginia Commonwealth University

  lead OTHER

Principal Investigators

• Alison Breland, PhD · Virginia Commonwealth University

Study Design

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

55 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2019-01-15

Primary Completion

2020-03-09

Completion

2020-03-09

Countries

• United States

Study Locations