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Examination of Low Wattage and High Wattage E-Cigarettes

NCT03113136 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 372

Last updated 2026-04-17

Study results available
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Summary

The overall aim of the proposed study is to evaluate the effect of switching from conventional cigarettes to either a LWe or HWe on smoking behavior, product use patterns and continued use, as well as biomarkers of toxicant exposure and effects.

Conditions

  • Smoking, Cigarette
  • Smoking, Tobacco
  • Nicotine Dependence
  • Exposure to Toxic Agent

Interventions

BEHAVIORAL

High wattage E cigarette device

The high wattage E cigarette device will be provided to the participant and they will be instructed to vape ad libitum for 12 weeks and then be assessed at 6 months and 12 months for continued use of device.

BEHAVIORAL

Usual brand cigarette

The usual brand of cigarettes will be provided to the participant and they will be instructed to smoke ad libitum for the duration of the study.

BEHAVIORAL

Low wattage E cigarette device

The low wattage E cigarette device will be provided to the participant and they will be instructed to vape ad libitum for 12 weeks and then be assessed at 6 months and 12 months for continued use of device.

Sponsors & Collaborators

  • National Institutes of Health (NIH)

    collaborator NIH

  • National Cancer Institute (NCI)

    collaborator NIH

  • University of Minnesota

    collaborator OTHER

  • Ohio State University Comprehensive Cancer Center

    lead OTHER

Principal Investigators

  • Theodore Wagener, PhD · Ohio State Comprehensive Cancer Center

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-06-29
Primary Completion
2022-01-31
Completion
2022-01-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03113136 on ClinicalTrials.gov