Effects of E-Cigarette Nicotine Content in Smokers (Nicotine Flux Study)

Summary

This study aims to better understand how e-cigarettes (ECIG) nicotine flux impacts several behavioral economic measures of abuse liability.

Conditions

• Electronic Cigarette Use

Interventions

OTHER

Tobacco product administration and assessment, own brand cigarettes

4 sample puffs, followed by a 60 minute rest period, hypothetical drug purchase tasks, followed by progressive ratio tasks (single product and two products, with 60 minute rest in between) where participants work to earn puffs of tobacco products; preceded and followed by physiological and subjective assessment

OTHER

Tobacco product administration and assessment, ECIG 30 Watts, 0 mg/ml nicotine

4 sample puffs, followed by a 60 minute rest period, hypothetical drug purchase tasks, followed by progressive ratio tasks (single product and two products, with 60 minute rest in between) where participants work to earn puffs of tobacco products; preceded and followed by physiological and subjective assessment

OTHER

Tobacco product administration and assessment, ECIG 30 Watts, 8 mg/ml nicotine

4 sample puffs, followed by a 60 minute rest period, hypothetical drug purchase tasks, followed by progressive ratio tasks (single product and two products, with 60 minute rest in between) where participants work to earn puffs of tobacco products; preceded and followed by physiological and subjective assessment

OTHER

Tobacco product administration and assessment, ECIG 30 Watts, 15 mg/ml nicotine

4 sample puffs, followed by a 60 minute rest period, hypothetical drug purchase tasks, followed by progressive ratio tasks (single product and two products, with 60 minute rest in between) where participants work to earn puffs of tobacco products; preceded and followed by physiological and subjective assessment

OTHER

Tobacco product administration and assessment, ECIG 30 Watts, 30 mg/ml nicotine

4 sample puffs, followed by a 60 minute rest period, hypothetical drug purchase tasks, followed by progressive ratio tasks (single product and two products, with 60 minute rest in between) where participants work to earn puffs of tobacco products; preceded and followed by physiological and subjective assessment

Sponsors & Collaborators

• National Institute on Drug Abuse (NIDA)

  collaborator NIH

• Virginia Commonwealth University

  lead OTHER

Principal Investigators

• Caroline O Cobb, PhD · Virginia Commonwealth University

• Andrew Barnes, PhD · Virginia Commonwealth University

Study Design

Allocation

NA

Purpose

BASIC_SCIENCE

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Max Age

55 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2021-01-05

Primary Completion

2023-06-01

Completion

2023-09-08

Countries

• United States

Study Locations