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Inter-Individual Variability in Early Diet-Induced Thermogenesis After a Standardized Meal

NCT07610759 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2026-05-28

No results posted yet for this study

Summary

This study aims to characterize how individuals differ in their metabolic response to food intake, specifically focusing on early diet-induced thermogenesis (DIT). DIT refers to the increase in energy expenditure that occurs after eating and reflects the body's metabolic response to processing nutrients.

Healthy adult participants will complete a single laboratory visit under standardized conditions. Resting metabolic rate will first be measured, followed by consumption of a standardized liquid meal (550 kcal). Energy expenditure will then be continuously monitored for 3 hours using indirect calorimetry.

The primary objective is to quantify inter-individual variability in early postprandial thermogenesis. Rather than estimating total daily energy expenditure, this study focuses on the early metabolic response following meal ingestion. Findings will improve understanding of differences in metabolic efficiency between individuals and support future research in metabolism and personalized nutrition.

Conditions

  • Diet-induced Thermogenesis

Interventions

OTHER

Standardized Liquid Meal

Consumption of a standardized liquid meal (\~550 kcal) under controlled laboratory conditions, followed by continuous measurement of energy expenditure using indirect calorimetry for assessment of postprandial thermogenesis. The procedure is used for measurement purposes only and is not intended as a therapeutic intervention.

Sponsors & Collaborators

  • Tel Aviv University

    lead OTHER

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-06-30
Primary Completion
2027-06-30
Completion
2027-06-30

Countries

  • Israel

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07610759 on ClinicalTrials.gov