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Acute Effects of Creatine and L-Arginine Co-Supplementation on Anaerobic and Cognitive Performance in Recreationally Active Males

NCT07548541 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 18

Last updated 2026-04-23

No results posted yet for this study

Summary

This randomized, double-blind, four-period crossover trial investigates the acute effects of creatine monohydrate, L-arginine, and their combined administration on anaerobic performance, jump performance, and cognitive reaction time in recreationally active adult males. Eighteen healthy male participants complete four experimental conditions in randomized order: placebo, creatine, L-arginine, and creatine plus L-arginine, with at least 72 hours between sessions. Sixty minutes after supplementation, participants perform the Stroop Color-Word Test, countermovement jump test, and Running-Based Anaerobic Sprint Test. Primary outcomes include peak power, average power, countermovement jump height, and incongruent Stroop reaction time. The study aims to determine whether acute co-supplementation produces greater ergogenic and cognitive benefits than either supplement alone or placebo.

Conditions

  • Anaerobic Performance
  • Cognitive Performance
  • Healthy Volunteers

Interventions

DIETARY_SUPPLEMENT

Creatine Monohydrate

Acute oral creatine monohydrate supplementation at 0.3 g/kg body mass.

DIETARY_SUPPLEMENT

L-Arginine

Acute oral L-arginine supplementation at a dose of 6 g.

OTHER

Placebo

Placebo beverage containing 6 g sucrose dissolved in 250 mL of water.

Sponsors & Collaborators

  • Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia

    collaborator UNKNOWN

  • Inonu University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-04-01
Primary Completion
2025-05-15
Completion
2025-05-16

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07548541 on ClinicalTrials.gov