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Effects of L-Arginine and Citrulline Malate Supplementation on Sport Performance in Physically Active Men

NCT06938126 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 46

Last updated 2025-04-22

No results posted yet for this study

Summary

In this randomized, double-blind, placebo-controlled trial we investigated the effects of combined L-arginine (Arg) and citrulline-malate (CM) supplementation on aerobic, anaerobic, and high-intensity interval training in healthy, physically active men. 46 healthy, physically active men were divided into three distinct exercise protocol groups: CrossFit group, the Wingate Anaerobic Test group, and the Harvard Step Test group. The CrossFit performance assessment involved the "Cindy" workout, a high-intensity protocol composed of bodyweight exercises organized in a set sequence: 5 pull-ups, 10 push-ups, and 15 squats. Participants were instructed to perform as many rounds as possible within 20 minutes. The Wingate Anaerobic test involved a 30-second all-out cycling test on a bike ergometer, while the Harvard Step Test The Harvard Step Test was conducted using a 51 cm high platform, with participants stepping at a rate of 30 steps per minute (one second up, one second down) for five minutes or until exhaustion. Each participant attended three separate laboratory sessions. The initial session served for familiarization with the test protocol to minimize learning effects. In the second and the third sessions, participants attended two measurement sessions, conducted in randomized order and under double-blind conditions, where they received either the dietary supplementation or a placebo. Each participant acted as their control, allowing for within-subject comparisons.

Conditions

  • Healthy

Interventions

DIETARY_SUPPLEMENT

L-Arginine and Citrulline-Malate Supplementation

L-Arginine and Citrulline Malate supplementation was consumed as a liquid one single time to examine the acute effects on sport performance

DIETARY_SUPPLEMENT

Placebo consumption

Consumption of placebo as a liquid

Sponsors & Collaborators

  • Hungarian University of Sports Science

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-10-01
Primary Completion
2024-05-15
Completion
2024-09-30

Countries

  • Hungary

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06938126 on ClinicalTrials.gov