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The Effect of Antioxidant Vitamin Supplementation on Muscle Performance and Redox Status After Eccentric Training

NCT01290458 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 28

Last updated 2011-02-07

No results posted yet for this study

Summary

Consumption of vitamin supplements is a common practice among athletes or people participating in health promoting exercise programs. The reason for this interest in vitamin supplements is primarily because of the observation that enhanced production of reactive oxygen and nitrogen species (RONS) influence fundamental biological processes, such as gene expression, signal transduction and enzyme activity. In a muscle and exercise physiology context, a low level of RONS is required for normal force production, whereas marked increases in RONS can cause contractile dysfunction, resulting in muscle weakness and fatigue. On the other hand RONS are involved in signaling pathways and serve to up-regulate the expression of a number of genes and can exert favorable effects such as training adaptations.

The present study will employ a valid eccentric exercise model to examine the influence of combined vitamin C and E supplementation after acute and chronic eccentric exercise on muscle damage and performance, redox status, hemolysis and lipid and lipoprotein profile.

Conditions

  • Muscle Damage
  • Oxidative Stress
  • Hemolysis

Interventions

DIETARY_SUPPLEMENT

Antioxidant vitamins

Oral supplementation with one tablet of 1 g of vitamin C (Lamberts Healthcare Ltd, UK) and one tablet of 400 IU of vitamin E (Lamberts Healthcare Ltd, UK)

Sponsors & Collaborators

  • European University Cyprus

    collaborator OTHER

  • Greek Ministry of Development

    collaborator OTHER_GOV

  • Democritus University of Thrace

    collaborator OTHER

  • University of Thessaly

    lead OTHER

Principal Investigators

  • Athanasios Z Jamurtas, Dr · University of Thessaly

Study Design

Allocation
NON_RANDOMIZED
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-06-30
Primary Completion
2009-11-30
Completion
2010-06-30

Countries

  • Greece

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01290458 on ClinicalTrials.gov