Expanded Studies on the SCAPIS Stockholm Reexamination Cohort

Summary

The Swedish CArdioPulmonary bioImage Study (SCAPIS) is a unique, large-scale national research initiative involving 30,000 randomly selected individuals aged 50-64, recruited between 2014 and 2018. The study is a collaborative effort among six university hospitals across Sweden. A follow-up study, SCAPIS 2, is conducted for half of the original participants. In Stockholm, 2,500 individuals will be re-examined at Danderyd University Hospital and Karolinska Institutet.

SCAPIS 2 includes a core set of examinations involving blood sampling, questionnaires, and imaging. In addition to these, complementary local investigations are conducted to enable more detailed research questions. This protocol describes the additional studies conducted in the Stockholm cohort. All complementary assessments aim to identify risk factors for current and future lung, liver, and cardiovascular diseases.:

EXTENDED SAMPLING: Saliva and Blood Samples with Blood Cell Isolation. EXTENDED QUESTIONNAIRES: Dyspnea, Sleep, Respiratory Infections, and Dental Health.

EXTENDED IMAGING AND PHYSIOLOGICAL MEASUREMENTS Cardiac Ultrasound and Abdominal Aortic Measurements. Liver Elastography. Vascular Stiffness by cuff-based pulse wave analysis and Photoplethysmography (PPG). Valvular and Vascular Calcification by CT imaging.

Conditions

• Coronary Artery Disease
• Arterial Stiffness, Blood Pressure
• AORTIC VALVE DISEASES
• Mitral Valve Stenosis and/or Insufficiency
• Heart Failure
• Pulmonary Disease, Chronic Obstructive (COPD)
• Steatohepatitis
• Inflammation Biomarkers
• Lipid Profile
• Oral Microbiota
• MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
• Metabolic Associated-dysfunction Steatohepatitis (MASH)

Interventions

DIAGNOSTIC_TEST

Coronary computer tomography (CCTA)

Siemens Naeotom Alpha Photon Counting CT scanner

DIAGNOSTIC_TEST

Echocardiograhy and aortic ultrasound

Echocardiograhy and aortic ultrasound using General Electric Vivid E95

DIAGNOSTIC_TEST

Liver elastography

Liver elastography using Fibroscan ultrasound method.

DIAGNOSTIC_TEST

Arterial stiffness

Arterial stiffness using Arteriograph, Tensiomed, Hungary and Photoplethysmography and ECG by ADInstrument

Sponsors & Collaborators

• Region of Stockholm

  collaborator UNKNOWN

• Karolinska Institutet

  collaborator OTHER

• Göteborg University

  collaborator OTHER

• Danderyd Hospital

  lead OTHER

Principal Investigators

• Rebecka Hultgren · Karolinska Institutet

• Karin Leander · Karolinska Institutet

• Paolo Parini · Karolinska Institutet

• Daniel Andersson · Karolinska Institutet

• Matteo Pedrelli · Karolinska Institutet

• Apostolos Bossios · Karolinska Institutet

• Georgios Belibasakis · Karolinska Institutet

• Tomas Jernberg · Karolinska Institutet

• Hannes Hagström · Karolinska Institutet

• Magnus Bäck · Karolinska Institutet

• Bahira Shahim · Karolinska Institutet

• Zhichao Zhou · Karolinska Institutet

Eligibility

Min Age

56 Years

Max Age

74 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2024-04-08

Primary Completion

2026-03-30

Completion

2026-08-30

Countries

• Sweden

Study Locations