Role of Pro-Resolving Lipid Mediators in Obesity-Associated Diseases

Summary

The main objective of this project is to determine the possible association between the levels of certain bioactive lipids, which the body produces from dietary fatty acids, and tumor characteristics in breast cancer patients, as well as their relationship with overweight/obesity.

Specific objectives are:

* To analyse anthropometric and body composition changes.
* To evaluate physical activity level.
* To determine dietary profile.
* To determine the adherence to Mediterranean dietary pattern.
* To assess the quality of life.
* To determine levels of specialized pro-resolving lipid mediators

The target sample size is 60 subjects. Participants will be allocated in four groups:

* Group 1: Postmenopausal healthy women with overweight/obesity (n=15)
* Group 2: Postmenopausal healthy women with normoweight (n=15)
* Group 3: Postmenopausal women with breast cancer and overweight/obesity (n=15)
* Group 4: Postmenopausal women with breast cancer and normoweight (n=15)

Conditions

• Breast Cancer
• Health, Subjective
• Obesity

Interventions

OTHER

Observational study (baseline)

Data will be collected at a single time point.

OTHER

Observational study (baseline and 1 year)

Data will be collected at two time points during the study period.

Sponsors & Collaborators

• Clinica Universidad de Navarra, Universidad de Navarra

  lead OTHER

Principal Investigators

• Miguel Burgos, PhD · Center for Nutrition Research

• María Jesús Moreno-Aliaga, PhD · Center for Nutrition Research

• María Soledad García-Unciti, PhD · Center for Nutrition Research

• Idoia Ibero-Baraibar, PhD · Center for Nutrition Research

• Iosune Zubieta · Center for Nutrition Research

• Salomé Pérez · Center for Nutrition Research

• Asunción Redín · Center for Nutrition Research

• Andrea Lara · Center for Nutrition Research

• María Pilar Lostao, PhD · Center for Nutrition Research

• Natalia Rodríguez-Spiteri, PhD · Clínica Universidad de Navarra

• Begoña Olartecoechea, PhD · Clínica Universidad de Navarra

• Ángel Vizcay, PhD · Clínica Universidad de Navarra

• Marta Santisteban, PhD · Clínica Universidad de Navarra

Eligibility

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2025-10-15

Primary Completion

2027-11-30

Completion

2027-12-30

Countries

• Spain

Study Locations