Role of Nutrition and Maternal Genetics on the Programming of Development of Fetal Adipose Tissue

Summary

In the PREOBE projects it is aimed to obtain genetic and biochemical biomarkers for the programming of obesity in early stages of life. This can be achieved by studying pregnant women with normal weight, overweight, obesity and gestational diabetes, and by analyzing how these conditions could impact on fetal growth and development; the risk of obesity in the offspring during the first 3 years of life will be also assessed (genetic polymorphisms of the most recognized genes related to obesity; gene expression of placental biomarkers indicators of early programming, polyunsaturated fatty acids, immunological and pro-inflammatory markers, analysis of endogenous and exogenous lipid peroxidation, allergies \& neurodevelopmental assessment...). Moreover, the interaction of pathological maternal conditions with confounder factors that could have a role in the proposed outcomes will be also studied (maternal and child dietary intake, medical history and socioeconomic \& environmental factors).

Conditions

• Obesity
• Diabetes

Sponsors & Collaborators

• Ministerio de Economía y Competitividad, Spain

  collaborator OTHER_GOV

• Abbott

  collaborator INDUSTRY

• Scottish Government NuGO EU Project

  collaborator UNKNOWN

• University of Barcelona

  collaborator OTHER

• ICTAN-CSIC - Madrid - Spain

  collaborator UNKNOWN

• Ludwig-Maximilians - University of Munich

  collaborator OTHER

• University of Nottingham

  collaborator OTHER

• University of Aberdeen

  collaborator OTHER

• Andalusian Agency of Knowledge

  collaborator OTHER_GOV

• Universidad de Granada

  lead OTHER

Principal Investigators

• Cristina Campoy, Professor, MD · Universidad de Granada

Eligibility

Min Age

18 Years

Max Age

42 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2007-03-31

Primary Completion

2010-10-31

Completion

2013-06-30

Countries

• Spain

Study Locations