MedTrace Logo

A Natural History Study of Angelman Syndrome

NCT07417137 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2026-05-18

No results posted yet for this study

Summary

The goal of this observational study is to learn about the natural progression of Angelman syndrome (AS) in children and adults with a confirmed genetic diagnosis of AS. The main questions it aims to answer are:

* How do developmental skills, such as communication, motor abilities, and adaptive behaviors, change over a 1-year period in people with AS?
* Are there specific patterns in brain activity or sleep that are associated with changes in AS symptoms over time?

Participants will:

* Visit the study site 5 times over 1 year (approximately every 3 months) for assessments.
* Complete tests and questionnaires about development, behaviors, and sleep with the help of their caregivers.
* Undergo electroencephalograms (EEGs) to measure brain activity and wear a sleep-monitoring device at home (to collect actigraphy data).

Conditions

Sponsors & Collaborators

Principal Investigators

  • Christopher J Keary, MD · Massachusetts General Hospital

Eligibility

Min Age
1 Year
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-06-30
Primary Completion
2028-09-30
Completion
2029-09-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07417137 on ClinicalTrials.gov