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The Role of Granulation Tissue in Periodontal Regeneration

NCT07254117 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 46

Last updated 2025-11-28

No results posted yet for this study

Summary

The goal of this observational study is to distinguish the infectious, healing, and regeneration-related characteristics of two types of gingival granulation tissues, namely infra-osseous and supra-osseous granulation tissues, in people with severe periodontitis (gum disease). Researchers aim to denote if these tissues may play role in healing after periodontal treatment. Researchers will also compare smokers and non-smokers to see if smoking disrupts the healing potential or infectious properties of granulation tissue. Participants will provide gingival fluid (before) and granulation tissue samples (at the time of) periodontal surgery. The main questions this study aims to answer are: 1. Do infra- and supra-osseous granulation tissues have different healing potential and infectious properties? 2. How do these tissues differ in people who smoke compared to people who do not smoke?

Conditions

  • Periodontal Bone Loss
  • Periodontitis
  • Periodontal Disease
  • Periodontal Diseases
  • Periodontal Regeneration
  • Periodontal Granulation Tissue
  • Vertical Periodontal Bone Defects
  • Periodontal Healing

Sponsors & Collaborators

  • University of Turku

    collaborator OTHER

  • Riga Stradins University

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-05-29
Primary Completion
2026-09-30
Completion
2026-09-30

Countries

  • Latvia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07254117 on ClinicalTrials.gov