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The Effects Of I-PRF On Gingivectomy and Gingivoplasty

NCT05871190 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 46

Last updated 2023-05-23

No results posted yet for this study

Summary

The study aims to evaluate the effects of injectable platelet-rich fibrin (I-PRF) applications on early wound healing after gingivectomy and gingivoplasty surgery. In this randomized controlled single-blind study, gingivectomy and gingivoplasty surgeries were performed on 46 patients. The postoperative I-PRF-applied surgery areas were compared with control regions. The surgical areas were stained with Mira-2 tone and evaluated in the ImageJ program. Wound healing was evaluated by using the Modified Manchester Scar (MMS) scale and Landry, Turnbull, and Howley (LTH) index. Vascular endothelial growth factor (VEGF) and fibroblast growth factor 10 (FGF-10) concentrations were assessed by enzyme-linked immunoabsorbent assay (ELISA). The seven-day Visual Analog Scale was used to assess pain level.

Considering the results found, I-PRF applications revealed positive effects on epithelial wound healing after gingivectomy and gingivoplasty operations.

Conditions

  • Wound Heal

Interventions

OTHER

İnjectable platelet rich fibrin

I-PRF is a type of platelet-rich fibrin (PRF) product obtained from the patient's own blood. PRF is a kind of tissue regeneration product of blood, rich in platelets, growth factors and cellular components.

PROCEDURE

Gingivectomy anad gingivoplasty

leveling and regulation of the gingiva

Sponsors & Collaborators

  • Afyonkarahisar Health Sciences University

    collaborator OTHER

  • Saglik Bilimleri Universitesi

    lead OTHER

Principal Investigators

  • şeyma ÇARDAKCI BAHAR, Lecturer · University of Health Sciences; Ankara, Turkey

  • Nebi Cansın KARAKAN, Asst. Prof. · Faculty of Dentistry Afyonkarahisar University of Health Sciences, Afyonkarahisar, Turkey

  • Ayhan VURMAZ, Assoc. Prof. · Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
15 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-08-23
Primary Completion
2022-03-15
Completion
2022-05-20

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05871190 on ClinicalTrials.gov