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Grape Extract and Exercise Effects on Blood Pressure

NCT06985407 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2026-05-06

No results posted yet for this study

Summary

Exercise and grape extract intake (i.e., polyphenol-rich product) can independently improve blood pressure and endothelial function in prehypertensive individuals. Nevertheless, their combined effects remain unexplored. Furthermore, since the biological pathways targeted by both interventions are similar, they could overlap and be amplified by one another, promoting additive or synergistic effects. Animal model studies have reported that a grape seed extract intake prevents exercise-induced oxidative stress, which could improve vascular dysfunction. Furthermore, as previously reported, a single dose of grape seed extract reduces blood pressure, peripheral vasoconstriction, and heart stress, enhancing O2 delivery during exercise in prehypertensive males. These effects may be partly due to endothelium-dependent vasodilation enhancement. Therefore, it is necessary to understand the potential impact of exercise and grape extract on blood pressure and vascular function in prehypertensive individuals.

Conditions

  • Exercise Response
  • Blood Pressure Monitoring, Ambulatory
  • Polyphenol

Interventions

DIETARY_SUPPLEMENT

Grape extract (VinteraTM Premium OPC)

Each condition will last 7 days for assessing both acute and chronic effects, and there will be a wash-out period of 7 days.

DIETARY_SUPPLEMENT

Control (placebo) group

Each condition will last 7 days for assessing both acute and chronic effects, and there will be a wash-out period of 7 days.

Sponsors & Collaborators

  • University of Castilla-La Mancha

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
25 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-02-10
Primary Completion
2026-05-05
Completion
2026-05-05

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06985407 on ClinicalTrials.gov