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Characterizing Transcranial Focused Ultrasound Neuromodulation During Sedation

NCT07161518 · Status: ENROLLING_BY_INVITATION · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2026-03-10

No results posted yet for this study

Summary

The goal of this clinical trial is to learn if focused ultrasound delivered to the brain influences the effects of the anesthetic medication propofol. It will also learn about the safety and feasibility of using ultrasound and anesthesia together to influence the brain. The main questions it aims to answer are:

* Does focused ultrasound delivered to the brain influence the effects or the strength of propofol?
* Does propofol anesthesia influence the effects of ultrasound delivered to the brain?

Researchers will compare focused ultrasound with sham ultrasound (similar technology but not targeted to a brain region) and administer propofol anesthesia, while measuring signals from the brain and behaviors of participants.

Participants will:

* Obtain one non-contrast MRI scan of the brain
* Receive two separate sessions of ultrasound to the brain (one focused and one sham)
* Undergo two separate sessions of propofol anesthesia in a laboratory

Conditions

  • Healthy Participants

Interventions

DEVICE

Low-intensity transcranial ultrasound

Active (focused) ultrasound

DEVICE

Low-intensity transcranial ultrasound

Sham (unfocused) ultrasound

DRUG

Propofol

Intravenous propofol administration

Sponsors & Collaborators

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-09-01
Primary Completion
2027-08-31
Completion
2027-08-31
FDA Drug
Yes
FDA Device
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07161518 on ClinicalTrials.gov