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Atrioventricular Nodal Ablation Versus Pulmonary Vein Isolation - Patient Centred Decisions

NCT07059208 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 172

Last updated 2025-07-14

No results posted yet for this study

Summary

The goal of this clinical trial is to compare two procedural approaches to managing atrial fibrillation. The main questions it aims to answer are:

Is AF ablation or pacemaker implant and AV nodal ablation a more effective treatment approach for patients with atrial fibrillation refractory to pharmacological treatment?

What effect do these differing treatment approaches have on patient's quality of life and mental health?

Participants will:

Be randomly allocated to one of the treatment approaches. Visit the clinic 2 months, 12 months and 24 months after their procedure for a checkup, questionnaires and repeat heart ultrasounds.

Conditions

  • Atrial Fibrillation (AF)

Interventions

PROCEDURE

Atrioventricular nodal ablation

Patients randomised to this arm would undergo physiological pacing followed by atrioventricular nodal ablation

PROCEDURE

Pulmonary vein isolation

Patients randomised to this arm would undergo catheter ablation targeted at achieving pulmonary vein isolation

Sponsors & Collaborators

  • Sunshine Coast Hospital and Health Service

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-09-30
Primary Completion
2029-09-30
Completion
2031-09-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07059208 on ClinicalTrials.gov