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Clinical Value of Linear Ablation Without Pulmonary Vein Isolation in Persistent Atrial Fibrillation

NCT05468528 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 207

Last updated 2022-07-21

No results posted yet for this study

Summary

Based on previous theoretical foundation and clinical practice experience, the investigators further propose a multi-center randomized prospective trial to compare the pure linear ablation strategy without pulmonary vein isolation to traditional PVI ablation for persistent AF. population size is 207. The participants will be randomized to the linear ablation group and PVI ablation group with a 2:1 ratio. the follow-up period is 12 months. The primary outcome is freedom from atrial fibrillation, the secondary outcome is complications related to ablation.

Conditions

Interventions

PROCEDURE

catheter radiofrequency ablation(individualized stepwise linear without pulmonary vein isolation)

individualized stepwise linear ablation without pulmonary vein isolation

PROCEDURE

catheter radiofrequency ablation(PVI)

pulmonary vein isolation

Sponsors & Collaborators

  • First Affiliated Hospital, Sun Yat-Sen University

    collaborator OTHER

  • ZHONGNANSHAN MEDICAL FOUNDATION OF GUANGDONG PROVINCE

    collaborator UNKNOWN

  • Beijing Hospital

    collaborator OTHER_GOV

  • Wuhan Asia Heart Hospital

    collaborator OTHER

  • Tianjin Medical University General Hospital

    collaborator OTHER

  • Fuwai Yunnan Cardiovascular Hospital

    collaborator OTHER

  • RenJi Hospital

    collaborator OTHER

  • Chinese Academy of Medical Sciences, Fuwai Hospital

    collaborator OTHER

  • China National Center for Cardiovascular Diseases

    lead OTHER_GOV

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-08-01
Primary Completion
2024-05-01
Completion
2024-07-01

Countries

  • China

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05468528 on ClinicalTrials.gov