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Left Bundle Branch Area Pacing or Biventricular Pacing in AF and Left Ventricular Dysfunction

NCT06620705 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 34

Last updated 2024-10-01

No results posted yet for this study

Summary

It is unknown whether left bundle branch area pacing (LBBAP) or biventricular pacing best prevents or reverses left ventricular (LV) adverse remodelling in patients with atrial fibrillation (AF) who require ventricular pacing or CRT. This randomized non-inferiority cross-over trial will compare left ventricular end-systolic volume change and secondary endpoints between LBBAP and biventricular pacing in patients with AF and LV dysfunction.

Conditions

Interventions

DEVICE

Left bundle branch area pacing

Pacing of the left bundle branch area using a transvenous pacemaker lead

DEVICE

Biventricular pacing

Pacing of the right and left ventricle using transvenous pacemaker leads

Sponsors & Collaborators

  • Aarhus University Hospital

    collaborator OTHER

  • srdpiers

    lead OTHER

Principal Investigators

  • Sebastiaan Piers, MD, PhD · Leiden University Medical Center, Leiden, the Netherlands

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-09-10
Primary Completion
2027-09-30
Completion
2028-10-31
FDA Device
Yes

Countries

  • Denmark
  • Netherlands

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06620705 on ClinicalTrials.gov