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STrategies for Catheter Ablation of peRsistent Atrial Fibrlllation

NCT04428944 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 617

Last updated 2026-05-08

No results posted yet for this study

Summary

The objective of this study is to compare the efficacy of three different ablation strategies in patients with persistent AF:

1. PV antral isolation alone (PVAI)
2. PV antral isolation plus ablation of drivers (PVAI+drivers)
3. PV antral isolation plus isolation of posterior wall (PVAI+box) All three strategies will employ contemporary catheter ablation technology using more efficient open irrigated tip cooling and contact force sensing.

Conditions

Interventions

PROCEDURE

Wide Circumferential Pulmonary Vein Antrum Isolation (PVAI)

Standard PVI

PROCEDURE

Pulmonary Vein Antrum Isolation Plus Driver Ablation (PVAI+drivers)

Standard PVI + Ablation of drivers in LA and RA

PROCEDURE

Pulmonary Vein Antrum Isolation Plus Box Isolation of Posterior Wall (PVAI+box)

Standard PVI + Electrical isolation of the posterior wall of the left atrium

Sponsors & Collaborators

  • Montreal Heart Institute

    collaborator OTHER

  • McGill University Health Centre/Research Institute of the McGill University Health Centre

    lead OTHER

Principal Investigators

  • Atul Verma, Dr. · McGill University Health Centre/Research Institute of the McGill University Health Centre

  • Laurent Macle, Dr. · Montreal Heart Institute

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-06-01
Primary Completion
2027-09-30
Completion
2027-12-31

Countries

  • United States
  • Australia
  • Austria
  • Belgium
  • Canada
  • France
  • Italy
  • Japan
  • Spain

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04428944 on ClinicalTrials.gov