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ABLATE Versus PACE: PVI or AV Node Ablation and PM Implantation for Elderly Patients With Persistent AF

NCT04906668 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 196

Last updated 2025-09-17

No results posted yet for this study

Summary

As patients age, symptom control and treatment of atrial fibrillation become equally difficult, often leading to increased hospitalization. ABLATE versus PACE is a prospective, randomized clinical trial comparing pacemaker implantation with AV node ablation with pulmonary vein isolation in terms of rehospitalization and quality of life in patients with persistent AF aged 75 years and older.

Conditions

Interventions

PROCEDURE

Cryoballoon pulmonary-vein isolation

Electrical isolation of the pulmonary-veins using cryoenergy

PROCEDURE

Pacemaker implantation and ablation of atrioventricular-node

Pacemaker implantation and ablation of atrioventricular-node

Sponsors & Collaborators

  • The German Heart Foundation

    collaborator OTHER

  • St. Josefs-Hospital Wiesbaden GmbH

    lead OTHER

Principal Investigators

  • Joachim Ehrlich, MD · St. Josefs-Hospital Wiesbaden GmbH

  • Andreas Boehmer, MD · St. Josefs-Hospital Wiesbaden GmbH

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
75 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-05-01
Primary Completion
2026-05-30
Completion
2027-04-30

Countries

  • Austria
  • Germany

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04906668 on ClinicalTrials.gov