Effects of Peripheral Magnetic Stimulation on Cortical Excitability in Healthy Individuals

Summary

This study investigates the immediate effects of different parameters (frequency, intensity, and pulse number) of peripheral magnetic stimulation (rPMS) on cortical excitability in healthy individuals. Using a randomized, double-blind crossover design, the research aims to identify optimal stimulation protocols for modulating neural activity. Outcomes include measurements of motor-evoked potentials (MEPs), intracortical inhibition (ICI), and facilitation (ICF). Findings may enhance non-invasive therapeutic strategies for neurological disorders.

Conditions

• Healthy Individuals

Interventions

DEVICE

Peripheral magnetic stimulation (90% of RMT + 1 Hz)

Low-frequency stimulation (1 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.

DEVICE

Peripheral magnetic stimulation (90% of RMT + 10 Hz)

High-frequency stimulation (10 Hz) at 90% of resting motor threshold intensity, totaling 2400 pulses.

DEVICE

Peripheral magnetic stimulation (90% of RMT + 25 Hz)

High-frequency stimulation (25 Hz) at 90% of resting muscle threshold intensity, with 2400 pulses.

DEVICE

Peripheral magnetic stimulation (100% of RMT + 1 Hz)

Low-frequency (1 Hz), at resting motor threshold intensity (100%) protocol delivering 2400 pulses.

DEVICE

Peripheral magnetic stimulation (100% of RMT + 10 Hz)

High-frequency (10 Hz), at resting motor threshold intensity (100%) protocol delivering 2400 pulses.

DEVICE

Peripheral magnetic stimulation (100% of RMT + 25 Hz)

High-frequency (25 Hz), at resting motor threshold intensity (100%) protocol delivering 2400 pulses.

DEVICE

Peripheral magnetic stimulation (110% of RMT + 1Hz)

Low-frequency (1 Hz), above resting motor threshold intensity (110%) protocol delivering 2400 pulses.

DEVICE

Peripheral magnetic stimulation (110% of RMT + 10Hz)

High-frequency (10 Hz), above resting motor threshold intensity (110%) protocol delivering 2400 pulses.

DEVICE

Peripheral magnetic stimulation (110% of RMT + 25Hz)

High-frequency (25 Hz), above resting motor threshold intensity (110%) protocol delivering 2400 pulses.

Sponsors & Collaborators

• Universidade Federal de Pernambuco

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

40 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2022-10-01

Primary Completion

2025-09-30

Completion

2025-10-31

Countries

• Brazil

Study Locations