Emotional and Non-emotional Regulation in Patients With Emotional Instability and ADHD

Summary

The purpose of this study is to investigate how emotional and non-emotional regulation processes differ in EIP patients (with different levels of ADHD symptoms/ADHD-comorbidity) compared to controls. The investigators will test these participants' abilities to regulate emotional and non-emotional processes, reward anticipation and reward receipt while they undergo functional magnetic resonance imaging (fMRI). The participants' motor inhibition capacity on a behavioral level will also be investigated.

The hypothesis is that EIP patients will present with more deficits in emotion regulation processes compared to controls, even when controlling for ADHD symptoms. It is also hypothesized that higher levels of ADHD symptoms will correlate with dysfunctional non-emotional regulation processes, on a behavioral as well as brain mechanistic level.

Conditions

• Emotional Instability Personality Disorder (Borderline Personality Disorder)
• Attention Deficit Hyperactivity Disorder
• Healthy Controls

Interventions

OTHER

fMRI - Stroop task

2 x 10 minutes Stroop task (2 x 5 minutes emotional blocks, 2 x 5 minutes non-emotional blocks, order balanced across participants) performed during fMRI scan. See Detailed Study Description.

OTHER

fMRI - MID task

2 x 10 minutes MID task performed during fMRI scan. See Detailed Study Description.

BEHAVIORAL

Stop Signal Task

Performed at a computer at first visit, 10 minutes divided into 3 blocks. See Detailed Study Description.

OTHER

SCID-II

See Detailed Study Description.

OTHER

SDQ

See Detailed Study Description.

OTHER

ASRS

See Detailed Study Description.

OTHER

AQ

See Detailed Study Description.

OTHER

TAS-20

See Detailed Study Description.

OTHER

Raven's SPM

See Detailed Study Description.

OTHER

Reading ability

See Detailed Study Description.

OTHER

Ishihara's tests for colour deficiency

See Detailed Study Description.

OTHER

Additional questionnaire

including questions about somatic disease, current medication, BMI, smoking habits, first menstruation, last menstruation's first day, days without active oral contraceptive pill during last month, claustrophobia, vision impairment.

OTHER

Brown-ADD

See Detailed Study Description.

OTHER

MFQ

See Detailed Study Description.

OTHER

STAI-T

See Detailed Study Description.

OTHER

BIS

See Detailed Study Description.

OTHER

DAWBA

See Detailed Study Description.

OTHER

STAI-S

See Detailed Study Description.

OTHER

Sleepiness rating

Acquired 6 times while in MRI-scanner. See Detailed Study Description.

OTHER

Motivation rating

Acquired 6 times while in MRI-scanner. See Detailed Study Description.

BEHAVIORAL

FEFA2

Assessing ability to recognise emotional face, performed at a computer at first visit. See Detailed Study Description.

OTHER

Structural T1 MRI scan

See Detailed Study Description and Outcome Measures.

OTHER

Structural T2 MRI scan

See Detailed Study Description.

OTHER

DTI MRI scan

See Detailed Study Description and Outcome Measures.

OTHER

Resting state MRI scan

See Detailed Study Description and Outcome Measures.

Sponsors & Collaborators

• Karolinska Institutet

  lead OTHER

Study Design

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

16 Years

Max Age

18 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2016-08-31

Primary Completion

2017-12-31

Completion

2018-05-31