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Epidemiological Factors and Optimization of Conservative Approaches to Precancerous Lesions of Female Reproductive Organs

NCT06967740 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2025-07-31

No results posted yet for this study

Summary

The primary aim of this study is to develop a recommended clinical practice guideline for managing women with HPV HR (high-risk human papillomavirus) positivity and cervical lesions. Additionally, in collaboration with the Bioptic Laboratory, the study will analyze the integration of HPV HR testing into screening programs for women aged 35, 45, and 55, with a focus on optimizing management strategies for HPV HR-positive women.

Research Objectives:

* Evaluate spontaneous regression/progression over two years based on HPV HR genotyping (three groups - according to Alinity: high, intermediate, and low risk).
* Assess spontaneous regression/progression over two years based on HPV HR genotyping and viral load in HPV-vaccinated vs. non-vaccinated patients.
* Evaluate spontaneous regression/progression over two years based on methylation results.
* Assess spontaneous regression/progression over two years based on CinTec plus results.

Conditions

  • Cervical Cancer
  • Cervical Intraepithelial Neoplasia (CIN)
  • Risk Factors
  • Conservative Management

Sponsors & Collaborators

  • Nikola Janovska

    lead OTHER_GOV

Principal Investigators

  • Lukas Rob, Prof., MUDr., Csc. · University Hospital Kralovske Vinohrady

Eligibility

Min Age
18 Years
Max Age
46 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-11-01
Primary Completion
2028-12-31
Completion
2029-12-31

Countries

  • Czechia

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06967740 on ClinicalTrials.gov