Integrated Approach in Frail Older People with Atrial Fibrillation

Summary

The study will verify if a structured multidisciplinary approach (called iABC), aimed to improve the appropriate management of elderly AF patients with multimorbidity (the i-ABC group), would provide a clear evidence of an improvement in clinical conditions and quality of life compared to usual clinical care. The i-ABC group in AFFIRMO will follow the ABC pathway, focused on three domains: avoid stroke with anticoagulation (with optimized VKA or label-adherent DOAC use); better symptom management; and optimized management of associated cardiovascular and non cardiovascular comorbidities.

The study will be conducted in Bulgaria, Denmark, Italy, Romania, Serbia and Spain .

Conditions

• Atrial Fibrillation (AF)
• Hypertension
• Coronary Arterial Disease (CAD)
• Heart Failure
• COPD
• Peripheral Arterial Disease
• CKD
• Diabetes Mellitus
• Stroke
• TIA (Transient Ischemic Attack)

Interventions

OTHER

iABC platform use

The novel platform (iABC) that will be used in AFFIRMO will consist of an educational program, a healthy or functional diet/physical activity, guideline-adherent drug treatments, periodic (re)assessment.

Sponsors & Collaborators

• Aalborg University

  collaborator OTHER

• Faculty of Medicine, University of Belgrade

  collaborator UNKNOWN

• Universidad de Murcia

  collaborator OTHER

• Carol Davila University of Medicine and Pharmacy

  collaborator OTHER

• Plovdiv Medical University

  collaborator OTHER

• University of Liverpool

  collaborator OTHER

• Heart Care Foundation

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-04-11

Primary Completion

2026-01-31

Completion

2026-01-31

Countries

• Bulgaria
• Denmark
• Italy
• Romania
• Serbia
• Spain

Study Locations