Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM)

Summary

To compare two standard treatment strategies for atrial fibrillation: ventricular rate control and anticoagulation vs. rhythm control and anticoagulation.

Conditions

• Arrhythmia
• Atrial Fibrillation
• Cardiovascular Diseases
• Heart Diseases

Interventions

DRUG

amiodarone

DRUG

sotalol

DRUG

propafenone

DRUG

flecainide

DRUG

quinidine

DRUG

moricizine

DRUG

disopyramide

DRUG

procainamide

DRUG

adrenergic beta antagonists

DRUG

verapamil

DRUG

diltiazem

DRUG

digoxin

PROCEDURE

catheter ablation

DEVICE

pacemaker, artificial

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI)

  lead NIH

Principal Investigators

• H. Greene · Statistics and Epidemiology Research Corporation (S.E.R.C.)

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Eligibility

Min Age

65 Years

Max Age

100 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

1995-03-31

Completion

2002-09-30