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Salivary Fluoride Clearance

NCT06735235 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 27

Last updated 2024-12-16

No results posted yet for this study

Summary

This is a single-center, four-treatment, four-period crossover study. Over the course of the study, up to thirty qualified subjects will use four (4) study treatment products, one time each according to the randomization. Subjects will brush with 1.25g of the assigned study product at each visit. Subjects will provide saliva samples at baseline and at 2, 6, 12, and 30 minutes post-treatment. The F- concentrations in each saliva sample will be determined by ion chromatography

Conditions

  • Caries

Interventions

DRUG

0 ppm F

Each subject will be randomly assigned to this treatment during one of the four periods for this crossover study.

DRUG

250 ppm F as MFP

Each subject will be randomly assigned to this treatment during one of the four periods for this crossover study.

DRUG

1100 ppm as MFP

Each subject will be randomly assigned to this treatment during one of the four periods for this crossover study.

DRUG

2800 ppm F as MFP

Each subject will be randomly assigned to this treatment during one of the four periods for this crossover study.

Sponsors & Collaborators

  • Procter and Gamble

    lead INDUSTRY

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-07-14
Primary Completion
2021-07-29
Completion
2021-07-29

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06735235 on ClinicalTrials.gov